- Establish modeling and/or research informatics platform for emerging or established start-ups and biotech organizations using commercial – e.g. Schrödinger, Dotmatics, CDD Vault, Signals – and open source – Python, RDKit, ChemProp, PostgreSQL – solutions leveraging Amazon Web Services, Azure, Google Cloud or in house compute resources.
- Structure- and Ligand based molecular modeling projects.
- Machine Learning/AI solutions for on and off targets employing public and proprietary client data.
- Scientific laboratory and data workflow and analysis solutions.
- Specialized cheminformatics analysis of small and large data sets to guide lead molecule finding and drug candidate optimization.
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- Structure- and Ligand-based design.
- Predictive modeling and design of hetero-bifunctional degraders/glues.
- Covalent drug approaches - binding sites, residue/ligand reactivity, linkers.
- Dotmatics, CDD vault, Signals, Genedata etc. setup, customization, integration and administration of end to end LIMS and decision support systems.
- Vortex and Spotfire customization.
- Chemoinformatics and structural bioinformatics analyses.
- AI/ML in silico on and off target predictions.
- Pipelining tools – Pipeline Pilot, KNIME.
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Ligand Based Modeling
Structure Based Modeling
Johannes H. Voigt
CEO & Founder
25+ years drug discovery experience at big/midsize pharma, biotechs, and non-profit organizations.
25+ patents and applications.
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